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Metoclopramide and erythromycin are the two most commonly used agents used to manage gastroparesis and there is potential that the GLP-1 agonists will oppose the prokinetic effects of these agents Corticosteroids Corticosteroids are notorious for raising blood sugars which could directly oppose the blood sugar lowering effects of GLP-1 agonists

These alterations are the probable result of the lengthy cellular damage induced by MTX resulting in increased levels of ROS leading to DNA injury, oxidation, and proliferation inhibition

This scenario is supported by observations that correction of increased blood pressure by antihypertensive drugs is associated with a reduction in vascular oxidative stress

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In the retrieval or testing phase, the rat is placed in the illuminated area after 24 hours for recall and long-term memory evaluation